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Updated: May 16, 2025
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Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
Published on: November 19, 2019
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High-Purity CTC RNA Sequencing Identifies Prostate Cancer Lineage Phenotypes Prognostic for Clinical Outcomes
Marina N Sharifi1,2, Jamie M Sperger1,2, Amy K Taylor1,2
1Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin.
Cancer Discovery
|April 1, 2025
Abstract
Significance:
Treatment resistance remains a universal driver of lethal metastatic prostate cancer, associated with acquired genomic alterations and lineage transitions. Using a novel high-purity CTC isolation approach for CTC transcriptional profiling, we identified four lineage phenotypes differentially associated with prognosis in metastatic prostate cancer.
