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Updated: May 16, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Nickel-Catalyzed 1,1-Carboboration of Polysubstituted Internal Alkenes
Tong Yao1, Shiyang Wang1, Yu Liu1
1College of Chemistry and Life Science, Advanced Institute of Materials Science, Changchun University of Technology, Changchun, Jilin 130012, China.
Abstract:
Herein, we report a nickel-catalyzed 1,1-carboboration of di- and trisubstituted alkenyl boronates through a chain-walking strategy. This reaction effectively addresses the polarity-mismatch problem via ligand control, enabling the coupling of various carbon-based electrophiles while accommodating a broad range of functional groups. The approach yields diverse tetrasubstituted carbon gem-diboronate derivatives with exceptional regioselectivity. The synthetic utility of this method is further demonstrated through the concise synthesis of high-value bioactive molecules.
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