Related Experiment Video
Updated: May 16, 2025

Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice
Published on: November 16, 2011
[Rare cause of recurrent hypoglycemia]
Ifigeneia Barmpa1, Apostolos Chatzitomaris1, Eva Maria Lüngen1
1Klinik für Endokrinologie, Diabetologie und Geriatrie, Zentrum für Innere Medizin, Klinikum der Landeshauptstadt Stuttgart gKAöR Katharinenhospital, Stuttgart, Deutschland.
Abstract:
Non-islet cell tumor hypoglycemia (NICTH) is a rare cause of hypoglycemia, resulting from excessive secretion of insulin-like growth factor 2 (IGF-2) or pro-IGF‑2, which leads to subsequent activation of the insulin receptor. Doege-Potter syndrome is often used synonymously with NICTH, especially in cases with fibrous primary tumors in the thorax. In the current patient, tumor progression was observed over a short period without the possibility of debulking surgery. Therefore, oral therapy with prednisolone was initiated. Treatment with diazoxide or the somatostatin analogue octreotide is not recommended for NICTH.
More Related Videos
Related Concept Videos
Hypoglycemia and Glucagon
Diabetes Mellitus: Type 2 and Gestational
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Oral Hypoglycemic Agents: Glinides
Glucose Transporters
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:

