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Updated: May 16, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Transition-metal-catalyzed auxiliary-assisted C-H functionalization using vinylcyclopropanes and cyclopropanols
Shubhajit Basak1, Tripti Paul1, Santu Mandal1
1Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039, India. tpunni@iitg.ac.in.
Abstract:
Transition-metal-catalyzed chelation-assisted C-H functionalization exploiting small strained rings has surfaced as an appealing strategy, offering a robust platform for the construction of complex molecules in a step- and atom-economic fashion. In this vein, three-membered rings, viz. vinylcyclopropanes (VCPs) and cyclopropanols, have emerged as staple coupling partners due to their inherent ring strain. Moreover, their strain release serves as a potent driving force, unlocking new possibilities in molecular engineering via sequential C-H functionalization and ring scission. Recently, significant progress has been made in this emerging domain employing the aforementioned rings. This review article focuses on directing group (DG)-assisted C-H functionalization adopting VCPs and cyclopropanols as potential coupling partners until November 2024. The advancements are organized based on the type of functionalizations achieved.
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