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Updated: May 16, 2025

Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
Biocompatible silicomolybdic acid-promoted one-pot expeditious synthesis of 1,2,3-NH-triazoles
Danish Ansari1, Manoj K Jaiswal1, Mangal S Yadav1
1Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi, UP-221005, India. tiwari_chem@yahoo.co.in.
Abstract:
The present work describes a new and practical approach for the one-pot preparation of 4-aryl-NH-1,2,3-triazoles and 4-glycosyl-NH-1,2,3-triazoles from a multicomponent reaction involving aldehydes, nitroalkanes, and sodium azide in the presence of 5 mol% of silicomolybdic acid (SMA) as a versatile and biocompatible catalyst. One-pot sequential formation of C-C and C-N bonds, high reaction yield, biocompatible nature of catalyst, easy handling, and broad substrate scope of 1,2,3-triazoles are the notable advantages of the present protocol.
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