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An Investigation of the Effects of Sports-related Concussion in Youth Using Functional Magnetic Resonance Imaging and the Head Impact Telemetry System
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Brain Network Functional Connectivity in Children With a Concussion.

Adrian Onicas1, Stephanie Deighton2, Keith O Yeates3

  • 1TBI and Concussion Center, Department of Neurology, University of Utah School of Medicine, Salt Lake City.

Neurology
|April 1, 2025
PubMed
Summary
This summary is machine-generated.

Pediatric concussion alters brain network connectivity, with differences persisting up to six months post-injury. Age, sex, and symptom duration significantly impact these functional connectivity changes in children.

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Area of Science:

  • Neuroscience
  • Pediatric Medicine
  • Radiology

Background:

  • Pediatric concussion can disrupt functional brain network connectivity.
  • Longitudinal research is needed to understand recovery and identify factors influencing changes in brain function after concussion.

Purpose of the Study:

  • To investigate network functional connectivity (FC) up to 6 months after pediatric concussion.
  • To identify moderators of change in brain network connectivity following concussion in children.

Main Methods:

  • A prospective longitudinal observational study of children (8-17 years) with concussion or orthopedic injury (OI).
  • Resting-state fMRI scans were acquired acutely and at 3 or 6 months post-injury.
  • Linear mixed-effects models were used to analyze within-network and between-network FC, with adjustments for multiple comparisons.

Main Results:

  • Children with concussion showed lower between-network connectivity (visual-ventral attention) compared to OI.
  • Connectivity between visual and default mode networks was reduced at 6 months post-concussion.
  • Age, sex, and persistent symptom status moderated FC changes, with some differences emerging after clinical recovery.

Conclusions:

  • Functional connectivity differences, particularly between networks, emerge after pediatric concussion and can persist for up to 6 months.
  • Time after injury, age, sex, and persistent symptoms are key moderators of FC changes.
  • While within-network connectivity is preserved, between-network alterations may serve as objective biomarkers for lasting brain function changes.