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The Vestibulo-Ocular Reflex is Associated With Visuospatial Dysfunction in Patients With Parkinson's Disease
Yukang Kim1, Tonghoon Woo1, Seoui Kwag1
1Neurotology and Neuro-ophthalmology Laboratory, Korea University Medical Center, Seoul, South Korea.
Brain and Behavior
|April 2, 2025
Summary
Visuospatial deficits in Parkinson's disease (PD) may link to abnormal vestibulo-ocular reflex (VOR) function. This suggests VOR assessment could aid in understanding and treating cognitive issues in PD patients.
Area of Science:
- Neuroscience
- Cognitive Neurology
- Ophthalmology
Background:
- Visuospatial impairment is a common cognitive deficit in Parkinson's disease (PD).
- The relationship between vestibulo-ocular reflex (VOR) function and visuospatial abilities in PD patients is not well understood.
Purpose of the Study:
- To investigate the association between VOR function and visuospatial perception and memory in individuals with PD.
Main Methods:
- Prospective evaluation of 151 PD patients using video head-impulse tests to assess VOR gain.
- Rey Complex Figure Test (RCFT) was administered to evaluate visuospatial perception (copying) and memory (delayed recall).
Main Results:
- Abnormal RCFT-copying was associated with reduced VOR gain in the horizontal canal (p=0.007).
- Impaired RCFT-delayed recall correlated with lower Mini-Mental State Examination scores, older age, male sex, and more years of schooling, but not VOR gain.
- A significant portion of PD patients exhibited abnormal VOR gain (overestimation or decrease).
Conclusions:
- Vestibulo-ocular reflex (VOR) function may play a role in visuospatial perception and learning deficits observed in Parkinson's disease.
- Findings suggest potential for targeted therapeutic interventions and highlight the impact of PD on sensory-motor integration and cognition.
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