Bioinspired Suction-Driven Strategies with Nanoscale Skin-Controllable Adhesive Architectures for Efficient Liquid...

Area of Science:

• Biomaterials Science
• Drug Delivery Systems
• Nanotechnology

Background:

• Traditional transdermal drug delivery systems (TDDS) face challenges with skin barrier penetration, especially for large molecules and nanomaterials.
• Intelligent material-based structures are being integrated into TDDS to improve drug release efficiency and precision.
• The stratum corneum presents a significant physical barrier to conventional transdermal therapies.

Purpose of the Study:

• To provide a comprehensive review of suction-driven transdermal patches (SDAs).
• To highlight the integration of SDAs with multifunctional materials for stable adhesion and controlled drug release.
• To discuss the potential of bioinspired SDAs for localized and systemic drug delivery and future perspectives.

Main Methods:

• Review of suction-driven transdermal patch technologies inspired by bioinspired suction adhesion mechanisms.
• Emphasis on the optimization of multiscale cupping architectures for cost-effective and user-friendly devices.
• Discussion of negative pressure application to enhance skin adhesion and facilitate therapeutic agent penetration.

Main Results:

• Suction-driven architectures (SDAs) offer innovative solutions to overcome skin barrier limitations in TDDS.
• These systems utilize negative pressure for enhanced skin adhesion and deep penetration of therapeutic agents.
• Optimized cupping structures enable cost-effective, user-friendly, and needle-free drug delivery platforms.

Conclusions:

• Bioinspired SDAs represent a promising minimally invasive, needle-free platform for efficient transdermal drug delivery.
• These systems enhance drug delivery efficiency and user convenience by temporarily bypassing the skin barrier.
• Future directions focus on patient-centric solutions for challenging skin delivery scenarios.