Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Fractures: Bone Repair01:27

Fractures: Bone Repair

2.8K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
2.8K
Phases of Wound Repair01:28

Phases of Wound Repair

5.7K
Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
5.7K
Bone Remodeling01:40

Bone Remodeling

38.0K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.0K
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

2.7K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Biocompatibility of silk fibroin nanofibers scaffold with olfactory ensheathing cells].

Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery·2009
Same author

[Association of tryptophan hydroxylase gene A218C and serotonin transporter gene polymorphism with essential hypertension in Chinese northern Han population].

Zhonghua xin xue guan bing za zhi·2009
Same author

An FES cycling control system based on CPG.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2009
Same author

One example on how colloidal nano- and microparticles could contribute to medicine.

Nanomedicine (London, England)·2009
Same author

[Mutational analysis of Meq, RLORF4, RLORF12 and 132bpr genes of epidemic Marek's disease virus strains highly passaged on chicken embryo fibroblast].

Bing du xue bao = Chinese journal of virology·2009
Same author

Dietary fish oil n-3 polyunsaturated fatty acids and alpha-linolenic acid differently affect brain accretion of docosahexaenoic acid and expression of desaturases and sterol regulatory element-binding protein 1 in mice.

The Journal of nutritional biochemistry·2009

Related Experiment Video

Updated: May 16, 2025

Author Spotlight: Effectiveness of Extracorporeal Shockwave Therapy in Achilles Tendinopathy Treatment
03:50

Author Spotlight: Effectiveness of Extracorporeal Shockwave Therapy in Achilles Tendinopathy Treatment

Published on: August 2, 2024

932

Cracking the code: Understanding ESWT's role in bone fracture healing.

Nan Jing1, Yi-Chen Hou1, Jia-Chang Zhang1

  • 1Department of Rehabilitation Medicine, CNPC Central Hospital, Langfang, 065000, PR China.

Journal of Orthopaedic Translation
|April 2, 2025
PubMed
Summary

Extracorporeal shock wave therapy (ESWT) offers a promising non-invasive treatment for bone non-union. This review explores how ESWT regulates osteoblasts and osteoclasts to enhance bone fracture healing.

Keywords:
Extracorporeal shock wave treatmentFracture non-unionOsteoblastOsteoclast

More Related Videos

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects
07:35

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects

Published on: April 11, 2012

17.4K
Protocol for Developing a Femur Osteotomy Model in Wistar Albino Rats
05:43

Protocol for Developing a Femur Osteotomy Model in Wistar Albino Rats

Published on: August 31, 2022

2.6K

Related Experiment Videos

Last Updated: May 16, 2025

Author Spotlight: Effectiveness of Extracorporeal Shockwave Therapy in Achilles Tendinopathy Treatment
03:50

Author Spotlight: Effectiveness of Extracorporeal Shockwave Therapy in Achilles Tendinopathy Treatment

Published on: August 2, 2024

932
Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects
07:35

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects

Published on: April 11, 2012

17.4K
Protocol for Developing a Femur Osteotomy Model in Wistar Albino Rats
05:43

Protocol for Developing a Femur Osteotomy Model in Wistar Albino Rats

Published on: August 31, 2022

2.6K

Area of Science:

  • Orthopedics
  • Regenerative Medicine
  • Biomaterials

Background:

  • Bone non-union presents significant challenges in orthopedic treatment, impacting patient quality of life and incurring socioeconomic costs.
  • Current treatments, primarily surgical, have limitations including persistent non-union in some cases and contraindications for certain patients.
  • There is a clinical need for alternative, effective, and safe treatments for bone fractures.

Purpose of the Study:

  • To review the mechanisms by which Extracorporeal Shock Wave Therapy (ESWT) promotes bone fracture healing.
  • To elucidate the role of ESWT in regulating osteoblasts and osteoclasts in the context of bone non-union.
  • To provide a theoretical basis for the clinical application of ESWT as a non-invasive therapeutic option.

Main Methods:

  • Literature review focusing on studies investigating the effects of ESWT on bone healing.
  • Analysis of research detailing the molecular and cellular mechanisms of ESWT.
  • Examination of the impact of ESWT on osteoblast and osteoclast activity.

Main Results:

  • ESWT demonstrates efficacy comparable to surgical interventions for bone non-union with improved safety profiles.
  • The therapy influences bone healing by modulating the activity of key cellular players: osteoblasts (bone formation) and osteoclasts (bone resorption).
  • Understanding these mechanisms provides a foundation for optimizing ESWT protocols.

Conclusions:

  • Extracorporeal shock wave therapy (ESWT) presents a viable non-invasive alternative for treating bone non-union.
  • ESWT's ability to regulate osteoblast and osteoclast activity is central to its bone healing promotion.
  • This review supports the further clinical investigation and application of ESWT in orthopedic practice.