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Updated: May 16, 2025

Rapid One-step Enzymatic Synthesis and All-aqueous Purification of Trehalose Analogues
Published on: February 17, 2017
Understanding the role of trehalose in interactions between Wolbachia and Aedes aegypti
Benjamin Dupuis1, Nicolas Pocquet2, Anna-Bella Failloux1
1Institut Pasteur, Université Paris Cité, Arboviruses and Insect Vectors, Paris, France.
Abstract:
Mosquito-borne diseases such as chikungunya, dengue, and Zika represent a major burden on global public health. To fight against these arboviruses, vector control strategies are a priority. One existing strategy is based on the use of an endosymbiotic bacterium, Wolbachia, which reduces the transmission of arboviruses by the mosquito Aedes aegypti via a pathogen blocking effect. Wolbachia in Ae. aegypti disrupts several pathways of the host's metabolism. Trehalose is a carbohydrate circulating mainly in insect hemolymph and plays a role in numerous mechanisms as energy source or stress recovery molecule and in chitin synthesis. This study explores the importance of trehalose in the interactions between Wolbachia and Ae. aegypti, and attempts to understand the pathogen blocking effect.
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