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Updated: May 16, 2025

Novel Sequence Discovery by Subtractive Genomics
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Open-source implementation of X-nuclear sequences using the Pulseq framework.

Xiaoxi Liu1, Di Cui1, Peder E Z Larson1

  • 1Department of Radiology and Biomedical Imaging, University of California, California, USA.

Magnetic Resonance in Medicine
|April 2, 2025
PubMed
Summary
This summary is machine-generated.

Researchers developed vendor-neutral MRI sequences and a GE scanner interpreter for X-nuclear imaging. This enables reproducible multi-site studies across different MRI vendors and software versions for advanced research.

Keywords:
X‐nuclear MRImulti‐vendor MRIopen sourcepulse sequence programmingvendor‐neutral

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Area of Science:

  • Magnetic Resonance Imaging
  • Spectroscopy
  • Medical Physics

Background:

  • Standardized MRI sequences are crucial for multi-site research.
  • GE scanners require specific interpreters for advanced imaging techniques.
  • X-nuclear MRI offers unique insights into biological processes.

Purpose of the Study:

  • To create vendor-neutral, modular MRI sequences for X-nuclear acquisitions.
  • To develop an X-nuclear-enabled Pulseq interpreter for GE scanners.

Main Methods:

  • Designed modular 2D gradient echo spiral and 3D balanced steady-state free precession sequences.
  • Developed the TOPPE MNS Pulseq interpreter for GE scanners.
  • Evaluated sequences and interpreter using phantom and in vivo studies (31P, 2H, 13C).

Main Results:

  • Modular sequences demonstrated accuracy and consistency with product sequences.
  • Phantom and in vivo studies confirmed accurate excitation and spatial encoding.
  • High image quality and SNR were achieved in human and animal studies, showing reproducibility.

Conclusions:

  • Successfully designed modular X-nuclear MRI sequences and a GE interpreter.
  • The developed tools facilitate multi-site studies across MRI vendors.
  • This work advances the standardization and accessibility of X-nuclear MRI research.