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POLARIZATION-SENSITIVE OPTICAL COHERENCE TOMOGRAPHY FEATURES OF THE REPAIR TISSUE AFTER RETINAL PIGMENT EPITHELIUM
Keiko Azuma1, Daisuke Santo2, Satoshi Sugiyama2
1Department of Ophthalmology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Purpose:
To investigate changes in melanin distribution and retinal sensitivity after a retinal pigment epithelium tear in neovascular age-related macular degeneration.
Methods:
Five cases of neovascular age-related macular degeneration with retinal pigment epithelium tears involving the fovea within 1 month of onset were examined. Using polarization-sensitive optical coherence tomography, entropy-a quantitative indicator of melanin distribution-was measured at baseline and 6 months at the level of Bruch membrane. Retinal sensitivity was assessed with a microperimeter, and entropy was averaged across 25 grids within a 6° radius. The relationship between changes in entropy and retinal sensitivity was analyzed.
Results:
Entropy significantly increased in the tear area (from 0.18 to 0.22, P< 0.0001), whereas it decreased in the nontear area. Retinal sensitivity also significantly increased in the tear area (from 12.7 to 16.3 dB, P <0.0001). Although entropy and retinal sensitivity were not directly correlated in each area, their changes were significantly correlated, regardless of area type. Changes in central grid entropy were associated with changes in logarithm of the minimum angle of resolution visual acuity.
Conclusion:
Six months postretinal pigment epithelium tear, entropy and retinal sensitivity increased in tear areas; entropy changes were linked to retinal sensitivity and visual acuity, indicating functional adjustments after the tear.
