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Relapse Risk in Patients with Membranous Nephropathy after Inactivated COVID-19 Vaccination.

Hanzhen Zhang1, Ruiying Chen1, Mingyue Xu1

  • 1Division of Nephrology, Huashan Hospital, Fudan University, Shanghai, China.

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Summary
This summary is machine-generated.

Inactivated COVID-19 vaccination did not increase the risk of relapse or worsening for patients with membranous nephropathy. This study found similar outcomes in vaccinated and unvaccinated individuals, suggesting vaccine safety for this patient group.

Keywords:
COVID-19Membranous nephropathyRelapseVaccinationWorsening of membranous nephropathy

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Area of Science:

  • Nephrology
  • Immunology
  • Vaccinology

Background:

  • Reports suggest potential relapse or worsening of membranous nephropathy post-COVID-19 vaccination.
  • Causal relationship between COVID-19 vaccines and membranous nephropathy exacerbation remains unestablished.

Purpose of the Study:

  • To investigate the occurrence of relapse or worsening of membranous nephropathy following inactivated COVID-19 vaccination.
  • To assess the impact of inactivated COVID-19 vaccination on membranous nephropathy outcomes.

Main Methods:

  • Retrospective study of 353 membranous nephropathy patients (186 vaccinated, 167 unvaccinated).
  • Monitored relapse/worsening within 12 months in patients with proteinuria <3.5 g/d.
  • Used cardinality matching to balance baseline variables between vaccinated and unvaccinated groups.

Main Results:

  • No significant difference in relapse or worsening rates between vaccinated (13%) and unvaccinated (15%) groups after matching.
  • Hazard ratio for relapse/worsening was 0.98 (95% CI 0.42-2.33) in vaccinated vs. unvaccinated patients.
  • Unvaccinated patients cited concerns about disease relapse and vaccine efficacy due to immunosuppressive therapy.

Conclusions:

  • Inactivated COVID-19 vaccination does not appear to increase the risk of relapse or worsening in patients with membranous nephropathy.
  • Findings suggest that inactivated COVID-19 vaccines are likely safe for individuals with membranous nephropathy.