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[Identification of genes regulating human CAR-T cell proliferation by genome-wide CRISPR screening]

Yoshitaka Adachi1,2

  • 1Department of Hematology and Oncology, Nagoya University Graduate School of Medicine.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|April 2, 2025
PubMed
Summary

Cul5 gene knockout enhances chimeric antigen receptor T-cell (CAR-T) therapy efficacy by improving CAR-T cell proliferation and function. This CAR-T cell enhancement leads to better tumor suppression in vivo.

Keywords:
CAR-T therapyCRISPR screeningCUL5ubiquitin system

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