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Published on: December 22, 2020
High-Efficiency ICG Molecular Vibration Therapy for Bradyarrhythmia Using Cardiomyocyte-Based Biosensing
Xuelian Lyu1, Tao Liang1,2, Jilin Zheng1
1Department of Chemistry, Zhejiang-Israel Joint Laboratory of Self-Assembling Functional Materials, ZJU-Hangzhou Global Scientific and Technological Innovation Center, School of Medicine, Zhejiang University, Hangzhou 310058, China.
A novel photothermal therapy using indocyanine green (ICG) offers a noninvasive treatment for bradyarrhythmia. This drug-mimicking strategy effectively enhances cardiomyocyte electrophysiology, providing a promising alternative to conventional therapies.
Area of Science:
- Biomedical Engineering
- Cardiovascular Research
- Nanomedicine
Background:
- Bradyarrhythmia significantly contributes to cardiovascular disease morbidity and mortality.
- Current treatments like medication and surgery have limitations, including side effects and invasiveness.
- There is a critical need for alternative, less invasive therapeutic strategies for bradyarrhythmia.
Purpose of the Study:
- To develop and evaluate a universal, efficient drug-mimicking strategy for bradyarrhythmia treatment.
- To utilize the photothermal properties of indocyanine green (ICG) for therapeutic purposes.
- To establish an integrated cell-based biosensing-regulating platform for assessing treatment efficacy.
Main Methods:
- A drug-mimicking strategy employing near-infrared-triggered indocyanine green (ICG) was developed.
- An in situ integrated cell-based biosensing-regulating platform was created to monitor cardiomyocyte electrophysiology.
- The efficacy of ICG photothermal therapy was compared with Au nanorod plasmonic heating.
Main Results:
- ICG photothermal therapy demonstrated efficient enhancement of cardiomyocyte electrophysiology in bradyarrhythmia models.
- The treatment successfully maintained a rhythmic state in cardiomyocytes for extended periods.
- Thermal stimulation was identified as the key factor in improving cardiomyocyte electrophysiological activity.
Conclusions:
- This study presents a noninvasive, drug-mimicking photothermal treatment strategy for bradyarrhythmia using ICG.
- The developed biosensing-regulating platform provides a reliable method for electrophysiological assessment and drug screening.
- This approach holds significant potential for advancing bradyarrhythmia therapies.
