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DNA Packaging

DNA Packaging

Genomic DNA in Eukaryotes

Genomic DNA in Eukaryotes

Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.

Genomic DNA in Prokaryotes

Genomic DNA in Prokaryotes

The genome of most prokaryotic organisms consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the nucleoid. The chromosome is tightly wound, or supercoiled, for efficient storage. Prokaryotes also contain other circular pieces of DNA called plasmids. These plasmids are smaller than the chromosome and often carry genes that confer adaptive functions, such as antibiotic resistance.
Genomic Diversity in Bacteria
Although bacterial genomes are much...

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Related Experiment Video

Updated: May 17, 2025

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

Cell-Membrane-Anchored DNA Nanoplatform for Programming Cellular Interactions.

Mingshu Xiao¹, Li Li¹, Hao Pei²

¹School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China.

Methods in Molecular Biology (Clifton, N.J.)

|April 2, 2025

Summary

This summary is machine-generated.

Scientists developed a DNA nanoplatform to program cell-cell interactions, enhancing natural killer cell activity against cancer cells for improved immunotherapy.

Keywords:

Cell surface engineering Cell-based immunotherapy Cell–cell interactions DNA circuit Framework nucleic acid

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Last Updated: May 17, 2025

Folding and Characterization of a Bio-responsive Robot from DNA Origami

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Simple, Affordable, and Modular Patterning of Cells using DNA

Simple, Affordable, and Modular Patterning of Cells using DNA

Published on: February 24, 2021

Area of Science:

Biotechnology
Molecular Biology
Immunology

Background:

Programming cell-cell interactions is crucial for understanding multicellular behavior and developing cell-based therapies.
Current methods for controlling cellular interactions have limitations in precision and effectiveness.

Purpose of the Study:

To develop a novel cell-membrane-anchored DNA nanoplatform for programming cellular interactions.
To investigate the potential of this platform in modulating natural killer cell activity against cancer cells.

Main Methods:

Engineered cell-membrane-anchored framework nucleic acid nanostructures.
Utilized DNA probabilistic circuits to program nanoplatform clustering.
Assessed the modulation of natural killer cell recognition and cancer cell targeting.

Main Results:

Demonstrated successful programming of cellular interactions using the DNA nanoplatform.
Showcased enhanced recognition and targeting of cancer cells by natural killer cells.
Achieved improved cancer cell killing efficiency through modulated cellular interactions.

Conclusions:

The cell-membrane-anchored DNA nanoplatform offers a precise method for controlling cell-cell interactions.
This technology holds significant promise for advancing cell-based immunotherapy strategies.
Provides a foundation for developing novel therapeutic approaches targeting cancer through engineered cellular communication.