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Updated: May 16, 2025

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GLP-1RAs attenuated obesity and reversed leptin resistance partly via activating the microbiome-derived inosine/A2A

Chunyan Dong1, Bailing Zhou1, Binyan Zhao1

  • 1State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu 610041, China.

Acta Pharmaceutica Sinica. B
|April 3, 2025
PubMed

Keywords:
A2A pathwayGLP-1RAsGut microbiotaLeptin resistanceMacrophage-adipocyteMetaboliteObesityObesity-related inflammation

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