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RAB39B: A novel biomarker for acute myeloid leukemia identified via multi-omics and functional validation
Shuo Chen1,2,3, Mengxing Li1,2,3, Jishi Wang1,2,3
1Department of Hematology, Affiliated Medicine of Guizhou Medical University, Guiyang, 550001, China.
Background:
The objective of this research was to investigate the involvement of RAB39B in acute myeloid leukemia (AML) using bioinformatics analysis and in vitro experiments for validation.
Methods:
In this article, RNA sequencing data from The Cancer Genome Atlas and genotype-tissue expression were utilized to analyze the expression of RAB39BA and identify differentially expressed genes.
Results:
AML exhibited elevated expression of RAB39B in diverse tumor types. In laboratory experiments, it has been demonstrated that RAB39B exhibits a significant expression level in AML cell lines when compared to normal peripheral blood monocytes. Moreover, RAB39B is closely linked to the growth and programmed cell death of AML cells.
Conclusion:
In conclusion, RAB39B shows potential as a biomarker for the identification and prediction of AML, contributing to the growth and cell death processes in AML.
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