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Updated: May 16, 2025
Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors
Published on: September 27, 2019
Fatigue and itch severity in patients with PBC and PSC: Prospective analysis of two large cohorts
Beata Kruk1, Joanna Raszeja-Wyszomirska2, Marcin Krawczyk1,3
1Laboratory of Metabolic Liver Diseases, Department of General, Transplant and Liver Surgery, Centre for Preclinical Research, Medical University of Warsaw, Warsaw, Poland.
Abstract:
Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are rare liver diseases that significantly impair quality of life (QoL). In this study, we analysed two large cohorts comprising a total of 1267 patients with PBC and PSC, showing that fatigue is a frequent symptom in both conditions, particularly among females. Fatigue was associated with liver function markers (ALP/GGT in PSC) and with cirrhosis (in PBC). It was also often linked to cholestatic pruritus, further compromising QoL.
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