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OBOC screening of high activity and low-toxic polymyxin analogs against MCR-1 resistant strains
Wenhong Zheng1,2, Xin Wang1,2, Hao Lian2,3
1School of Bioscience and Technology Shandong Second Medical University Weifang, Shandong 261053, China. lill@bit.edu.cn.
Abstract:
We performed inverse synthesis to create 1152 structural analogs of polymyxin B with modified hydrophilicity and charge properties using OBOC technology. This led to the identification of two promising candidates that provided insights into structure-activity relationships. These compounds maintained high antibacterial activity while expanding the safety window 4-16 times.
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