Evaluation of protocol fidelity for prehospital antibiotic administration

Sepsis is a common, critical, time-sensitive medical emergency, with mortality rates of up to 56%. Early antibiotic administration is a cornerstone of sepsis management, yet prehospital antibiotic administration remains uncommon in the United States.

This prospective observational study evaluated the implementation of a prehospital sepsis protocol in an urban EMS system. Patients were eligible for prehospital antibiotic administration if they were ≥18 years old, hypotensive (SBP < 90 mm Hg), and febrile or hypothermic (<96.8°F or >100.4°F). Paramedics drew blood cultures and administered piperacillin/tazobactam or ceftriaxone. A report was generated to prospectively identify patients eligible for the study by hemodynamic data and/or if they were administered prehospital antibiotics. Demographic, operational, and clinical data were abstracted from patient care records and electronic health records. Outcomes were reported descriptively.

A sample of 147 patients was included for encounters from December 1, 2019, to December 1, 2024 (mean age 72.8 years, 31.3% female). Antibiotics were administered to 132 patients (89.8%). Of encounters with antibiotic administrations, 127/132 (96.2%) complied with the clinical protocol, and five (3.8%) were protocol violations. Additionally, six patients (4.1%) were inappropriately not administered antibiotics, and nine patients (6.1%) had contraindications to the protocol, so antibiotics were withheld. Of 356 blood culture bottles that underwent laboratory analysis, nine (2.5%) were contaminated. The mean (±SD) time from patient contact to antibiotics was 32.7 (±8.2) min.

Prehospital clinicians can reliably and safely administer antibiotics for sepsis with hypotension and severe sepsis, observing high protocol adherence and low contamination rates while expediting time from recognition of sepsis to first antibiotics. These findings support the integration of prehospital antibiotics into broader sepsis care pathways. Expanding such protocols could improve compliance with sepsis care quality measures and enhance patient outcomes, particularly in resource-constrained environments.