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Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
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[Manifestations of progressive paralysis. Not a theme of the past]

A Risse, A Rohde, A Marneros

    Deutsche Medizinische Wochenschrift (1946)
    |August 2, 1985
    PubMed

    Insights

    The "classical form" of progressive paralysis is not consistently observed in patients. Key symptoms like megalomania and specific neurological signs are less common than previously believed.

    Area of Science:

    • Neurology
    • Psychiatry

    Context:

    • Progressive paralysis, a neurosyphilitic condition, has been historically characterized by a distinct clinical presentation.
    • Previous understanding suggested a uniform
    • classical form
    • of the disease.

    Purpose:

    • To investigate the prevalence of specific clinical and neurological signs in a large cohort of progressive paralysis patients.
    • To challenge the notion of a singular
    • classical form
    • of progressive paralysis.

    Summary:

    • A study of 293 progressive paralysis cases revealed significant variability in symptom presentation.
    • Megalomania occurred in only 13% of patients, and manic states in less than half.
    • Commonly cited neurological signs like the Argyll-Robertson phenomenon were exceptional rather than typical.

    Impact:

    • This research suggests that the clinical manifestations of progressive paralysis are more diverse than previously assumed.
    • It highlights that affective, drive, and intellectual disturbances are uncharacteristic and can occur across various psychotic syndromes.
    • The findings necessitate a re-evaluation of diagnostic criteria and understanding of progressive paralysis's spectrum.

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