Related Experiment Video
Updated: Feb 17, 2026

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model
Published on: March 16, 2022
[Charcot foot masked by erysipelas and peripheral arterial disease]
1Klinik für Dermatologie, Klinikum Dortmund gGmbH, Beurhausstr. 26, 44137, Dortmund, Deutschland. Annina.Haep@klinikumdo.de.
Insights
Charcot foot, a condition causing bone and joint destruction due to neuropathy, can be complicated by erysipelas and peripheral artery disease (PAD). Early diagnosis and treatment are crucial to prevent severe outcomes.
Area of Science:
- Podiatry
- Vascular Surgery
- Infectious Diseases
Background:
- Charcot foot (neuropathic arthropathy) involves aseptic bone and joint destruction.
- It stems from peripheral neuropathy, impaired pain perception, vasomotricity, and unequal weight distribution.
- Late diagnosis and incorrect treatment often lead to severe complications.
Observation:
- An 86-year-old man presented with erysipelas and necrosis of the right foot.
- He also had neuropathic arthropathy and radiological signs of Charcot foot.
- Peripheral artery disease (PAD) was identified as a third co-occurring diagnosis.
Findings:
- The patient experienced progressive deterioration despite antibiotic and vascular surgical interventions.
- Overlapping diagnoses of erysipelas, Charcot foot, and PAD complicated the clinical picture.
- Inflammation parameters increased, leading to a decline in the patient's overall health.
Implications:
- This case highlights the challenges in diagnosing and managing overlapping conditions like Charcot foot, erysipelas, and PAD.
- It underscores the importance of considering multiple diagnoses in complex foot conditions.
- Prompt and accurate diagnosis is critical for effective treatment and improved patient outcomes in neuropathic arthropathy.
Abstract:
Charcot foot is also known as Charcot disease or Charcot arthropathy. The associated aseptic destruction of the bones and joints of the foot results due to peripheral neuropathy accompanied by impaired pain perception, impaired vasomotricity with increased vasodilation, and an unequal weight distribution. Because it is frequently diagnosed late and, thus, incorrectly treated, serious complications often result. An 86-year-old man in poor health was diagnosed with erysipelas of the right foot. The foot was glossy and edematously swollen, showing necrosis of the distal phalanx of the third toe. The patient experienced pain after a walking distance of approximately 20 m. In addition to erysipelas, confirmed neuropathic arthropathy and radiological indicators for Charcot foot established peripheral artery disease (PAD) as a third diagnosis. Despite multiple systemic antibiotic therapies, there was a progressive disease pattern marked by increasing inflammation parameters with an increasing decline of the patient's overall health. The patient suffered severe deterioration in spite of vascular surgical measures, ultimately leading to his death. In the present case, the indicators and respective confirmation of the three overlapping diagnoses erysipelas, Charcot foot and PAD are elaborated.
Related Concept Videos
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
Peripheral Artery Disease I: Introduction
Peripheral Artery Disease IV: Nursing Management
Peripheral Artery Disease V: Postoperative Nursing Management
Endocarditis II: Clinical Features of Infective Endocarditis
Peripheral Artery Disease III: Interprofessional Care
