[Actinic keratoses : Current guideline and practical recommendations].

Area of Science:

• Dermatology
• Oncology

Background:

• The 2019 S3 guideline on actinic keratosis (AK) and squamous cell carcinoma (SCC) has faced subsequent scrutiny.
• New publications raise questions about data comparability and evaluation heterogeneity due to varied parameters and treatment considerations.

Purpose of the Study:

• To provide a concise overview of current developments and research concerning AK and SCC.
• To address criticisms and identify necessary advancements in the field.

Main Methods:

• Review of recent publications, reviews, and meta-analyses.
• Analysis of epidemiological data, pathogenesis, prevention, clinical presentation, and therapeutic options for AK and SCC.
• Inclusion of basic data, side effects, and features of therapeutic options for practical implementation.

Main Results:

• Therapeutic options for AK and SCC are categorized into local destructive procedures and topical applications.
• Recommendations are based on the current guideline, with evidence levels provided.
• Identified are divergent measurement parameters and insufficient consideration of pre-treatments and combined treatments as sources of heterogeneity.

Conclusions:

• The overview clarifies current developments and ongoing questions regarding actinic keratoses.
• Highlights the need for further research and development to refine treatment protocols and improve comparability of study data in skin cancer management.