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Does Fasting Triglyceride Level Influence Core Infarct Volume in Acute Stroke?
Surabhi Garg1, Tuqa Asedi2, Elyse Sandra Vetter2
1The Ottawa Hospital, University of Ottawa, Ottawa, ON.
The Neurologist
|April 3, 2025
Summary
Elevated triglyceride (TG) levels in acute ischemic stroke patients correlate with larger infarct volumes. This suggests hypertriglyceridemia may predict worse stroke outcomes and warrants further investigation as a therapeutic target.
Area of Science:
- Neurology
- Cardiology
- Metabolic Syndrome
Background:
- Hypertriglyceridemia is a common metabolic abnormality.
- Its role in acute ischemic stroke (AIS) severity, specifically infarct volume, requires further elucidation.
Purpose of the Study:
- To investigate the association between fasting triglyceride levels and initial infarct volume in AIS patients.
- To explore potential differences in this relationship across stroke etiologies.
Main Methods:
- Retrospective chart review and cross-sectional analysis of 178 AIS patients.
- Inclusion criteria: CTA/CTP within 24 hours, fasting triglycerides within 24 hours.
- Infarct volume calculated using RAPID software; statistical analyses performed using STATA.
Main Results:
- A significant positive association was found between triglyceride levels and infarct volume (P<0.01).
- Each unit increase in TG levels correlated with a 0.17 mL increase in infarct volume.
- Embolic stroke of undetermined source (ESUS) patients exhibited larger infarct volumes and higher mean TG levels.
Conclusions:
- Hypertriglyceridemia is linked to larger infarct volumes in AIS, particularly in ESUS.
- Elevated TG levels may indicate poorer stroke outcomes.
- Targeting hypertriglyceridemia could be a strategy for stroke prevention.
