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Updated: May 16, 2025
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Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
Published on: July 24, 2013
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Poor Sleep Quality is Associated With Frailty Among Women With and Without HIV
Anjali Sharma1, Donald R Hoover2, Qiuhu Shi3
1Department of Medicine, Albert Einstein College of Medicine, Bronx, NY.
Journal of Acquired Immune Deficiency Syndromes (1999)
|April 3, 2025
Summary
Poor sleep quality significantly increases frailty risk in aging women, including those with HIV. Daytime dysfunction and poor sleep efficiency are linked to frailty, while poor self-rated sleep and medication use are linked to prefrailty.
Area of Science:
- Gerontology
- Infectious Diseases
- Sleep Medicine
Background:
- Poor sleep and frailty are common in aging women, particularly those with HIV (WWH).
- Existing research on sleep-frailty links in general populations lacks specific characterization in WWH.
Purpose of the Study:
- To investigate the association between poor sleep quality and frailty in midlife women with and without HIV.
- To identify specific sleep components linked to frailty and prefrailty.
Main Methods:
- Analysis of Pittsburgh Sleep Quality Index (PSQI) and Fried Frailty Phenotype data from 1001 WWH and 371 women without HIV (WWoH) aged over 40.
- Hierarchical regression models adjusted for HIV status, demographics, substance use, medications, comorbidities, and depressive symptoms.
Main Results:
- Poor sleep quality was prevalent (52% WWH vs. 47% WWoH) and independently associated with doubled frailty odds (AOR 1.99).
- Daytime dysfunction and poor sleep efficiency were linked to frailty.
- Poor self-rated sleep and sleep medication use were linked to prefrailty.
Conclusions:
- Poor subjective sleep is independently associated with increased frailty risk in midlife women, irrespective of HIV status.
- Further longitudinal research is needed to explore sleep's role in frailty progression and its interplay with comorbidities in people with HIV.
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