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Vitamin D insufficiency and sleep disturbances in children with ADHD: a case-control study
Panpan Zhang1,2, Yang Liu1,2, Yan Ma1,2
1Department of Child Health, Dalian Municipal Women and Children's Medical Center (Group), Dalian, Liaoning, China.
Insights
Vitamin D insufficiency in children with Attention Deficit Hyperactivity Disorder (ADHD) significantly worsens sleep duration and disordered breathing. However, it does not directly impact ADHD symptoms or functional impairment. Screening for vitamin D deficiency is recommended for these children.
Area of Science:
- Pediatric Neurology
- Nutritional Neuroscience
- Sleep Medicine
Background:
- Attention Deficit Hyperactivity Disorder (ADHD) is a prevalent neurodevelopmental disorder frequently associated with sleep disturbances.
- Vitamin D plays a crucial role in regulating sleep patterns and supporting optimal brain function.
- The impact of vitamin D insufficiency on sleep problems and ADHD symptomology in children remains under-investigated.
Purpose of the Study:
- To investigate the relationship between vitamin D insufficiency and sleep problems in children diagnosed with ADHD.
- To determine if vitamin D deficiency exacerbates ADHD symptoms and functional impairment in pediatric populations.
Main Methods:
- A case-control study involving 260 children aged 6-14 years with ADHD.
- Participants were categorized into groups with vitamin D insufficiency (n=95) and sufficiency (n=165).
- Assessment included ADHD symptom severity, functional impairment scales, and the Children's Sleep Habits Questionnaire (CSHQ).
Main Results:
- Children with ADHD and vitamin D insufficiency exhibited significantly higher scores for sleep duration and sleep-disordered breathing compared to those with sufficient vitamin D levels.
- Overall, ADHD children demonstrated prevalent sleep problems, with CSHQ scores exceeding the threshold for concern.
- No direct correlation was found between vitamin D insufficiency and the type of ADHD, symptom severity, or functional impairment.
Conclusions:
- Sleep problems are common in children with ADHD, and vitamin D insufficiency is linked to increased sleep duration and sleep-disordered breathing.
- While vitamin D insufficiency does not directly worsen ADHD symptoms or functional impairment, its association with sleep disturbances highlights the need for screening.
- Addressing vitamin D levels in children with ADHD may be beneficial for managing associated sleep issues, potentially offering indirect improvements in overall well-being.
Introduction:
Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorders often co-occurring with sleep problems and other physical disorders. Vitamin D regulates sleep and supports normal brain function. Regrettably, no studies have looked at whether vitamin D insufficiency exacerbates sleep problems in ADHD children and further affects ADHD symptoms.
Objective:
This study aimed to examine whether vitamin D insufficiency exacerbates sleep problems and ADHD symptoms in children aged 6-14 years.
Methods:
This is a case-control study, 260 ADHD children (aged 6-14 years) were enrolled in, of whom 95 had vitamin D insufficiency and 165 had sufficiency. Collected all ADHD symptom severity and functional impairment scales, including Swanson, Nolan and Pelham (SNAP) scale, Integrated Visual and Auditory Continuous Performance Test (IVA-CPT), Conners parents symptom questionnaire (PSQ) and Weiss Functional Impairment Rating Scale-Parent Form (WFIRS-P). All guardians of children with ADHD complete the Children's Sleep Habits Questionnaire (CSHQ).
Results:
The CSHQ total scores of the ADHD children in both groups were significantly higher than 41, which means that ADHD children overall have sleep problems. Compared to ADHD children with vitamin D sufficiency group, we observed significantly higher sleep duration and sleep disordered breathing scores in ADHD children with vitamin D insufficiency group (all p< 0.05). However, there was no direct effect of vitamin D insufficiency on the type of ADHD, symptoms or functional impairment (all p> 0.05). Further analyses showed a correlation between the CSHQ and symptoms, functional impairment scores in children with ADHD.
Conclusion:
Sleep problems are highly prevalent in children with ADHD. Vitamin D insufficiency has a significant impact on both sleep duration and sleep disordered breathing, but no notable direct effects on ADHD symptoms or functional impairment. Our findings underscore the importance of screening for vitamin D insufficiency in children with ADHD, particularly given its association with sleep disturbances, which may indirectly affect symptom severity.
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