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Polymerized liposomes as stable oxygen-carriers.

J A Hayward, D M Levine, L Neufeld

    FEBS Letters
    |August 5, 1985
    PubMed
    Summary
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    Researchers created artificial red blood cells, or hemosomes, using polymerized lipid vesicles containing human hemoglobin. These novel oxygen carriers show potential for medical applications due to their stability and oxygen transport capabilities.

    Area of Science:

    • Biomaterials Science
    • Biochemistry
    • Nanotechnology

    Background:

    • Artificial red blood cells are being developed to address blood shortages and improve oxygen delivery.
    • Encapsulating hemoglobin within biocompatible vesicles is a promising strategy for creating oxygen carriers.

    Purpose of the Study:

    • To create and characterize polymerized erythrocyte-like vesicles (hemosomes) for potential use as artificial oxygen carriers.
    • To evaluate the stability, oxygen permeability, and hemocompatibility of these novel hemosomes.

    Main Methods:

    • Human hemoglobin was encapsulated within diacetylenic phospholipid vesicles using a freeze-thaw method.
    • Vesicles were polymerized via UV irradiation, forming stable polymeric hemosomes.
    • Hemoglobin entrapment, polymerization kinetics, heme oxidation, gas permeability, and oxygenation-deoxygenation were assessed.

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    Main Results:

    • Polymerized hemosomes were successfully produced with polymerization characteristics similar to protein-free liposomes.
    • Photo-induced heme oxidation was minimized by CO ligation and high intravesicular hemoglobin concentrations.
    • Allosteric effectors enabled efficient conversion to the oxyhemoglobin A form.
    • Spectroscopic methods confirmed gas permeability and reversible oxygenation-deoxygenation.

    Conclusions:

    • Polymerized hemosomes demonstrate sufficient gas permeability for potential in vivo oxygen carrier applications.
    • The apparent hemocompatibility of these hemosomes further supports their therapeutic potential.
    • These findings represent a significant advancement in the development of artificial red blood cell substitutes.