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Bioengineering ethics for the age of microphysiological systems.

Maxence Gaillard1,2

  • 1Centre for Medical Ethics, Department of Health and Society, Faculty of Medicine, University of Oslo, Oslo, Norway.

Frontiers in Bioengineering and Biotechnology
|April 4, 2025
PubMed
Summary

Engineering ethics are crucial for addressing novel challenges in microphysiological systems (MPS). Rethinking individual consent, collective deliberation, and the moral status of new entities is essential for responsible biomedical research advancements.

Keywords:
biobankingethics-by-designinformed consentmoral statusprecision medicine

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Area of Science:

  • Biomedical Ethics
  • Engineering Ethics
  • Regenerative Medicine

Background:

  • Microphysiological systems (MPS) like organoids and organs-on-chips present unprecedented ethical challenges.
  • Existing ethical frameworks struggle to accommodate the complexities of these advanced biotechnologies.

Purpose of the Study:

  • To argue for the necessity of an engineering ethics perspective to navigate new ethical dilemmas in MPS research.
  • To explore the evolving ethical considerations surrounding MPS development and application.

Main Methods:

  • Analysis of ethical implications concerning individual consent for biomaterial usage.
  • Examination of collective deliberation challenges related to stakeholder expectations and societal impact.
  • Discussion on the potential future moral status of complex MPS entities.

Main Results:

  • The traditional concept of informed consent requires reevaluation due to the extended lifecycle of biotechnologies using human biomaterial.
  • Managing societal expectations for animal replacement and advancements in precision/regenerative medicine poses a significant ethical challenge.
  • Future complex MPS may necessitate a redefinition of their moral status, impacting research practices.

Conclusions:

  • An engineering ethics framework is essential for addressing the ethical frontiers of microphysiological systems.
  • Ethical considerations must evolve to encompass individual consent, collective societal engagement, and the potential moral status of novel research entities.
  • Proactive ethical deliberation is vital for the responsible advancement of MPS in biomedical research.