Related Experiment Video

Updated: May 11, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

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Left Bundle Branch Pacing Improved the Outcome of End-Stage Hypertrophic Cardiomyopathy: A Case Report

Manxin Lin1, Shufen Huang1, Xinyi Huang2

  • 1Division of Cardiology, Xiamen Cardiovascular Hospital, Xiamen University, Xiamen, Fujian, China.

Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc
|April 4, 2025
PubMed

Insights

Left bundle branch pacing (LBBP) offers a promising treatment for end-stage hypertrophic cardiomyopathy (HCM) patients with reduced ejection fraction (EF) and left bundle branch block (LBBB). This case study highlights a remarkable recovery following LBBP, suggesting its potential efficacy where other methods failed.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Heart Failure Research

Background:

  • Hypertrophic cardiomyopathy (HCM) with advanced left ventricle enlargement and reduced ejection fraction (EF) signifies terminal stage disease.
  • Complete left bundle branch block (LBBB) in end-stage HCM is associated with poor prognosis.
  • Conventional biventricular pacing has shown limited benefits in similar patient cohorts.

Observation:

  • A patient presented with end-stage hypertrophic cardiomyopathy (HCM).
  • The patient also exhibited left ventricle enlargement, reduced ejection fraction (EF), and complete left bundle branch block (LBBB).
  • Previous treatments, including biventricular pacing, were considered potentially limited.

Findings:

  • Successful left bundle branch pacing (LBBP) was performed on the patient.
  • The patient experienced a significant and unexpected recovery.
  • This outcome contrasts with the limited efficacy of biventricular pacing in similar cases.

Implications:

  • Left bundle branch pacing (LBBP) may represent a novel and effective therapeutic strategy for end-stage hypertrophic cardiomyopathy (HCM).
  • LBBP could offer a better alternative for patients with reduced ejection fraction (EF) and left bundle branch block (LBBB).
  • Further research is warranted to explore the long-term benefits and mechanisms of LBBP in HCM.

Keywords:
cardiac resynchronization therapy (CRT)heart failurehypertrophic cardiomyopathy (HCM)left bundle branch block (LBBB)left bundle branch pacing (LBBP)

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