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Updated: May 16, 2025

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Isoquercitrin Alleviates Diabetic Nephropathy by Inhibiting STAT3 Phosphorylation and Dimerization

Chen Xuan1,2, Donghui Chen2,3, Shuangna Zhang2

  • 1School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|April 4, 2025
PubMed
Summary

Isoquercitrin effectively treats diabetic nephropathy by inhibiting signal transducer and activator of transcription 3 (STAT3). This natural compound, delivered via a novel nanocarrier, reduces kidney inflammation and fibrosis, offering a promising new therapy.

Keywords:
Iso@PEG‐GKSH2 domainSTAT3diabetic nephropathydimerizationisoquercitrinphosphorylation

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