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Microfluidics-Based Microcarriers for Live-Cell Delivery.

Zhonglin Fang1, Xinyuan Yang1, Chong Wang1

  • 1Shanghai Xuhui Central Hospital, Zhongshan-Xuhui Hospital, and the Shanghai Key Laboratory of Medical Epigenetics, the International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China.

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|April 4, 2025
PubMed
Summary
This summary is machine-generated.

Microfluidic technology enables the creation of advanced microcarriers for live-cell therapy, improving cell viability and efficacy in treating complex diseases. These microcarriers offer a protective environment crucial for therapeutic success.

Keywords:
cell therapylive‐cell deliverymicrocarriersmicrofluidics

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Area of Science:

  • Biotechnology
  • Regenerative Medicine
  • Materials Science

Background:

  • Live-cell therapy offers novel treatments for intractable diseases but faces challenges in maintaining cell viability and efficacy.
  • Microcarriers are essential for live-cell therapy, providing scaffolds that enhance cell retention, viability, and function.
  • Microfluidic technology offers precise control over microcarrier size and morphology, enabling high-throughput production.

Purpose of the Study:

  • To review recent advancements in microfluidics-based microcarriers for live-cell delivery.
  • To categorize the structural designs of microfluidic-derived cell-laden microcarriers.
  • To summarize the therapeutic applications of these microcarriers.

Main Methods:

  • Utilizing microfluidic liquid templates to fabricate various microcarrier types (microspheres, microfibers, microneedles).
  • Analyzing structural designs of microfluidic-derived cell-laden microcarriers.
  • Compiling and summarizing data on therapeutic applications.

Main Results:

  • Microfluidics enables the production of diverse microcarrier structures tailored for specific therapeutic needs.
  • Various microcarrier designs, including microspheres, microfibers, and microneedles, have been successfully developed.
  • These microcarriers demonstrate significant potential in enhancing live-cell therapy outcomes.

Conclusions:

  • Microfluidics-based microcarriers represent a significant advancement in live-cell therapy.
  • Further research into structural design and therapeutic applications will drive innovation in the field.
  • Addressing future challenges will unlock the full potential of microcarrier technology for treating intractable diseases.