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Regulation of Hormone Secretion01:19

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Organs-on-a-Chip Recapitulating the Gut-Islets Axis for Endocrine Hormone Secretion Regulator Evaluation.

Ji Sun1,2, Zhuhao Wu2, Jingbo Li1,2

  • 1Department of Endocrinology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China.

Research (Washington, D.C.)
|October 13, 2025
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Summary
This summary is machine-generated.

A novel organ-on-a-chip platform models the gut-islets axis to assess bile acids' impact on hormone secretion. This system accurately measures GLP-1 and insulin release, advancing metabolic drug discovery.

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Area of Science:

  • Biomedical Engineering
  • Endocrinology
  • Microfluidics

Background:

  • Organ-on-a-chip technology offers advanced in vitro modeling capabilities.
  • The gut-islets axis and its role in endocrine hormone regulation remain underexplored in chip-based systems.
  • Bile acids (BAs) are key regulators of gut-islet communication and glucose homeostasis.

Purpose of the Study:

  • To develop and validate an organ-on-a-chip platform for modeling the gut-islets axis.
  • To evaluate the effect of bile acids on the secretion of gut hormones and insulin.
  • To establish a novel system for metabolic drug discovery.

Main Methods:

  • Fabrication of a microfluidic chip with porous scaffolds using negative replication of droplet templates.
  • Co-culture of intestinal L-cells and pancreatic beta-cells within the scaffolds to form uniform spheroids.
  • Utilizing a cascading microfluidic system to generate bile acid concentration gradients for functional assays.

Main Results:

  • The platform successfully recapitulated the gut-islets axis characteristics.
  • Accurate assessment of bile acid concentrations on GLP-1 and insulin secretion was achieved.
  • Results demonstrated consistency with existing literature, validating the platform's accuracy.

Conclusions:

  • The developed organ-on-a-chip system provides a robust tool for studying the gut-islets axis.
  • This platform enables precise evaluation of bile acids' role in regulating endocrine hormone secretion.
  • The system holds significant potential for accelerating metabolic drug discovery and research.