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Related Experiment Videos

Recent advance in macrolactams: Structure, bioactivity, and biosynthesis.

Jiawei Qiu1, Ruochang Qin2, Shuai Zhi3

  • 1Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Health Science Center, Ningbo University, Ningbo, Zhejiang 315211, China; College of Food Science and Engineering, Ningbo University, Ningbo, Zhejiang 315832, China.

Bioorganic Chemistry
|April 4, 2025
PubMed
Summary

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Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
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This review summarizes 105 macrolactams discovered between 2004-2023 from diverse microbial sources. It details their structures, activities, and novel biosynthetic pathways, aiding future drug discovery.

Area of Science:

  • Natural Product Chemistry
  • Microbiology
  • Biotechnology

Background:

  • Macrolactams exhibit diverse structures and significant biological activities, driving research interest.
  • A systematic review of recent macrolactam advancements, including structure-activity relationships and novel biosynthetic pathways, is needed.

Purpose of the Study:

  • To compile and analyze macrolactams reported between 2004 and 2023.
  • To investigate their microbial sources, structural diversity, biological activities, and biosynthetic pathways.
  • To provide insights for future macrolactam discovery and sustainable production.

Main Methods:

  • Literature review of macrolactams reported from 2004-2023.
  • Analysis of microbial sources, isolation techniques, and structural characterization.
Keywords:
NRPS/PKS, PoTeMbiosynthesismacrolactamstructure-activity relationshipβ-amino acid

Related Experiment Videos

  • Examination of 17 known biosynthetic pathways, gene clusters, and enzyme mechanisms.

    • Main Results:

    • Compilation of 105 macrolactams from diverse environmental sources (marine, soil, plant, animal).
    • Detailed analysis of macrolactam structures, biological activities, and 17 distinct biosynthetic pathways.
    • Identification of key enzymes and gene clusters involved in non-collinear biosynthesis.

    Conclusions:

    • This review offers a comprehensive overview of recent macrolactam research.
    • It highlights the potential of microbial natural products for drug discovery.
    • It provides a foundation for synthetic biology approaches to macrolactam production.