Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Necrosis

Necrosis

Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Analytical Entropy Approach for Measuring Blockchain Immutability and Tamper-Resilient Trust.

Entropy (Basel, Switzerland)·2026

Same author

Intestinal interleukin-22 enhances GLP-1 production via the STAT3 pathway to improve glucose homeostasis during high-fat diet induced obesity in a study with male mice.

Nature communications·2026

Same author

Effects of 8 Weeks of Neuromuscular and SAQ Training on Physical Performance in Youth Soccer Players.

Journal of clinical medicine·2026

Same author

The postbiotic Lactobacillus kunkeei NCHBL-003 attenuates Mycobacterium abscessus-induced pulmonary inflammation by modulating IL-1β production.

Microbial pathogenesis·2026

Same author

Scrub Typhus among Febrile Patients Admitted to the Department of Medicine in a Tertiary Care Centre: A Descriptive Cross-sectional Study.

JNMA; journal of the Nepal Medical Association·2025

Same author

A Usefulness of Delta Neutrophil Index (DNI) for Prediction of 28 Day Mortality in Patients with Pneumonia-Induced Sepsis in the Intensive Care Unit.

Journal of clinical medicine·2025

Search research articles

Related Experiment Video

Updated: May 21, 2025

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Published on: March 15, 2024

Ferroptosis in neutrophils.

Yu-Bin Lee¹, Hyeong-Wook Shin¹, Sanjeeb Shrestha¹

¹Department of Physiology, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea.

Journal of Leukocyte Biology

|April 5, 2025

Summary

Ferroptosis, a cell death process involving iron and lipid peroxidation, significantly impacts neutrophils. Understanding its role in disease and immune regulation is key for new therapeutic strategies.

Keywords:

antioxidant defense ferroptosis lipid peroxidation neutrophils

More Related Videos

Direct Observation of Phagocytosis and NET-formation by Neutrophils in Infected Lungs using 2-photon Microscopy

Direct Observation of Phagocytosis and NET-formation by Neutrophils in Infected Lungs using 2-photon Microscopy

Published on: June 2, 2011

Ferritinophagy: Assessing the Selective Degradation of Iron by Autophagy in Human Fibroblasts

Ferritinophagy: Assessing the Selective Degradation of Iron by Autophagy in Human Fibroblasts

Published on: February 23, 2024

Related Experiment Videos

Last Updated: May 21, 2025

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Published on: March 15, 2024

Direct Observation of Phagocytosis and NET-formation by Neutrophils in Infected Lungs using 2-photon Microscopy

Direct Observation of Phagocytosis and NET-formation by Neutrophils in Infected Lungs using 2-photon Microscopy

Published on: June 2, 2011

Ferritinophagy: Assessing the Selective Degradation of Iron by Autophagy in Human Fibroblasts

Ferritinophagy: Assessing the Selective Degradation of Iron by Autophagy in Human Fibroblasts

Published on: February 23, 2024

Area of Science:

Cell Biology
Immunology
Biochemistry

Background:

Ferroptosis is regulated cell death driven by iron-dependent lipid peroxidation.
It involves intricate interactions of fatty acid, iron, and antioxidant metabolism.
Neutrophils are particularly susceptible to ferroptosis due to their cellular composition.

Purpose of the Study:

To review the mechanisms of ferroptosis in neutrophils.
To explore the implications of neutrophil ferroptosis in disease pathogenesis and immune regulation.
To identify potential therapeutic targets for ferroptosis-related conditions.

Main Methods:

Literature review of recent studies on ferroptosis in neutrophils.
Analysis of molecular mechanisms governing neutrophil ferroptosis susceptibility and resistance.
Examination of neutrophil extracellular trap-mediated ferroptosis induction.

Main Results:

Neutrophils are prone to ferroptosis, influenced by iron and polyunsaturated fatty acids.
Hypoxia can downregulate glutathione peroxidase 4, increasing ferroptosis susceptibility in some neutrophils.
Neutrophils can induce ferroptosis in other cells via neutrophil extracellular traps, contributing to various diseases.

Conclusions:

Neutrophil ferroptosis is a critical factor in disease progression and immune responses.
Dysregulated ferroptosis in neutrophils has implications for conditions like ischemia-reperfusion injury and cardiotoxicity.
Targeting ferroptosis pathways in neutrophils offers potential for novel therapeutic interventions.