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Updated: May 17, 2025
Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
Published on: February 19, 2021
Limited added value of systematic spinal cord MRI vs brain MRI alone to classify patients with MS as active or
Jérémy Hong1, Malo Gaubert1,2, Mathilde Lefort3
1Univ Rennes, CHU Rennes, Service de radiologie, 35000, Rennes, France.
Background:
The utility of systematic spinal cord (SC) MRI for monitoring disease activity after a multiple sclerosis (MS) diagnosis remains a topic of debate.
Objectives:
To evaluate the frequency of disease activity when considering brain MRI alone versus both brain and SC MRI and to identify factors associated with the occurrence of new SC lesions.
Methods:
We conducted a retrospective analysis of clinical and imaging data prospectively collected over 5 years as part of the EMISEP cohort study. A total of 221 intervals (with both brain and spinal cord MRI scans available at 2 consecutive time-points) from 68 patients were analysed. For each interval, brain (3D Fluid-Attenuated Inversion Recovery (FLAIR, axial T2 and axial PD) and SC MRI (sagittal T2 and phase-sensitive inversion recovery, axial T2*w and 3D T1) were reviewed to detect new lesions. Each interval was classified as symptomatic (with relapse) or asymptomatic. The baseline brain and SC lesion numbers were computed.
Results:
SC MRI activity without clinical relapse and/or brain MRI activity was rare (4 out of 221 intervals, 2%). The occurrence of a new SC lesion was associated with the number of brain lesions at baseline (OR = 1.002 [1.000; 1.0004], p = 0.015) and the occurrence of a new brain lesion during the interval (OR = 1.170 [1.041; 1.314], p = 0.009), but not with the baseline SC lesion number (p = 0.6).
Conclusion:
These findings support the current guidelines recommending routine disease monitoring with brain MRI alone, even in patients with a high SC lesion load.
