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Small intestinal function in chronic relapsing pancreatitis.

B Lembcke, B Kraus, P G Lankisch

    Hepato-Gastroenterology
    |June 1, 1985
    PubMed
    Summary
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    Chronic relapsing pancreatitis patients often have normal small intestine function. However, mild bacterial overgrowth may cause diarrhea and steatorrhea, even with pancreatic enzyme treatment.

    Area of Science:

    • Gastroenterology
    • Digestive Health
    • Pancreatic Diseases

    Background:

    • Chronic relapsing pancreatitis (CRP) can lead to malabsorption.
    • Steatorrhea is a common symptom, often treated with pancreatic enzyme replacement therapy (PERT).
    • The role of small intestinal function and bacterial overgrowth in CRP-related steatorrhea requires further investigation.

    Purpose of the Study:

    • To assess small intestinal function in patients with CRP.
    • To investigate the prevalence of lactase deficiency, D-xylose malabsorption, and vitamin B12 depletion.
    • To identify potential causes of persistent steatorrhea in CRP patients despite PERT.

    Main Methods:

    • Prospective study involving 20 patients with CRP.
    • Assessment of routine small intestinal function parameters.

    Related Experiment Videos

  • Utilized 14C-cholylglycine breath tests to detect bacterial overgrowth.

    • Main Results:

    • Routine small intestinal function tests were largely normal.
    • No significant lactase deficiency, D-xylose malabsorption, or vitamin B12 depletion observed.
    • A high incidence (40%) of abnormal 14C-cholylglycine breath tests indicated mild bacterial overgrowth.

    Conclusions:

    • Mild bacterial overgrowth, detected by breath tests, is common in CRP patients.
    • Bacterial overgrowth may contribute to diarrhea and steatorrhea.
    • Persistent steatorrhea in CRP patients, even with PERT, could be linked to bacterial overgrowth.