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Prospects of Ganoderma polysaccharides: Structural features, structure-function relationships, and quality

Yong Deng1, Jing Lei2, Xiao Luo3

  • 1School of pharmacy, Zunyi Medical University, Zunyi 563000, China; State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Beijing 100700, China.

International Journal of Biological Macromolecules
|April 5, 2025
PubMed
Summary
This summary is machine-generated.

Ganoderma polysaccharides (GPs) possess significant bioactivity linked to their structure. This review highlights GP structure-activity relationships and quality control methods for pharmaceutical and food applications.

Keywords:
Ganoderma polysaccharideQuality evaluationStructural characterizationStructure- activity relationships

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Area of Science:

  • Mycology
  • Pharmacology
  • Food Science

Background:

  • Ganoderma mushrooms contain polysaccharides (GPs) as primary bioactive compounds.
  • GP bioactivity is intrinsically linked to their physicochemical properties.
  • Current research faces limitations due to the complex structures of GPs.

Purpose of the Study:

  • To systematically review the structural features of Ganoderma polysaccharides (GPs).
  • To explore the relationships between GP structures and their bioactivities.
  • To outline current and needed quality control methods for GPs.

Main Methods:

  • Literature review focusing on Ganoderma polysaccharide research.
  • Analysis of studies on GP structural characterization.
  • Synthesis of information on structure-activity relationships and quality assessment.

Main Results:

  • Ganoderma polysaccharides (GPs) exhibit diverse biological activities.
  • Physicochemical properties significantly influence GP bioactivity.
  • A lack of standardized quality control methods hinders GP application.

Conclusions:

  • Accurate characterization of GP structure is crucial for understanding bioactivity.
  • Developing reliable quality control methods based on pharmacological activity is essential.
  • This review supports the pharmaceutical and functional food potential of Ganoderma polysaccharides.