Related Experiment Video
Updated: Jun 13, 2025

CRISPR/Cas9 Gene Editing of Hematopoietic Stem and Progenitor Cells for Gene Therapy Applications
Published on: August 9, 2022
Radioprotective agents against the ionizing radiation-induced hematopoietic stem and progenitor cell injury;
Amirhossein Ahmadi1, Zahra Nozhat2, Amir Shadboorestan3
1Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Abstract:
Humans encounter ionizing radiation (IR) through various ways, such as medical applications, agricultural industry, and potential exposure from radioactive materials or acts of radiological terrorism. Hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs) are crucial for maintaining the balance of blood cell lineages. The hematopoietic system, recognized as the most sensitive human tissue, is severely affected by IR, which can result in bone marrow (BM) failure, increased susceptibility to infections, hemorrhagic events, or anemia in affected individuals. Therefore, it is essential to develop radioprotective compounds to protect HSCs/HPCs. This review highlights several radioprotective agents that protect the hematopoietic system from IR-related damage to HSCs and HPCs and provides an overview of the mechanisms involved in damage and protection.
Related Concept Videos
Regulation of Hematopoietic Stem Cells
Stem Cell Therapy for Tissue Regeneration
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Multipotency of Hematopoietic Stem Cells
Hematopoiesis
Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
Role of Hematopoietic Growth Factors
Thrombopoietin (TPO), mainly released by the liver,...

