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Related Experiment Video

Updated: May 16, 2025

Standardized and Scalable Assay to Study Perfused 3D Angiogenic Sprouting of iPSC-derived Endothelial Cells In Vitro

Standardized and Scalable Assay to Study Perfused 3D Angiogenic Sprouting of iPSC-derived Endothelial Cells In Vitro

Published on: November 6, 2019

Engineering advanced in vitro models of endothelial dysfunction.

Jasneil Singh¹, Alexander M Ruhoff², Deepu Ashok³

¹School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, 2006, Australia; The Charles Perkins Centre, The University of Sydney, Sydney, NSW, 2006, Australia; The University of Sydney Nano Institute, The University of Sydney, Sydney, NSW 2006, Australia.

Trends in Biotechnology

|April 5, 2025

Summary

This summary is machine-generated.

Advanced in vitro models, like organs-on-chips, accurately replicate endothelial dysfunction, improving cardiovascular disease research and therapeutic discovery. These dynamic models overcome limitations of traditional methods for better human physiology insights.

Keywords:

atherosclerosis bioreactors endothelial cells endothelial dysfunction microfluidics organs-on-chips

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Last Updated: May 16, 2025

Standardized and Scalable Assay to Study Perfused 3D Angiogenic Sprouting of iPSC-derived Endothelial Cells In Vitro

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Published on: November 6, 2019

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Published on: July 19, 2024

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Published on: May 24, 2020

Area of Science:

Cardiovascular Research
Biomedical Engineering
Cellular Biology

Background:

Endothelial dysfunction initiates cardiovascular disease, a leading global cause of death.
It commonly occurs in arterial areas with abnormal blood flow.
Traditional experimental models have limitations in mimicking human physiology and ethical concerns.

Purpose of the Study:

To review advancements in in vitro models for studying endothelial dysfunction.
To explore the potential of next-generation in vitro models.
To highlight the role of dynamic models in therapeutic discovery.

Main Methods:

Focus on advanced in vitro models: organs-on-chips and bioreactors.
Comparison of in vitro models with traditional in vivo and preclinical methods.
Analysis of recent discoveries leveraging dynamic models.

Main Results:

Advanced in vitro models accurately replicate endothelial dysfunction using human cells and blood flow.
Organs-on-chips demonstrate superior accuracy compared to standard preclinical methods.
Dynamic models are crucial for identifying and evaluating potential therapeutics.

Conclusions:

In vitro models offer a more accurate and ethical approach to studying endothelial dysfunction.
Organs-on-chips represent a significant advancement in preclinical research.
Future development of next-generation in vitro models holds promise for cardiovascular disease research and treatment.