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[A Case of Advanced Gastric Cancer in Which Complete Pathological Response to Pre-Operative SOX and Nivolumab Therapy
Naoko Yoneura1, Eisuke Kondo, Kei Nishiya
1Dept. of Surgery, Japanese Red Cross Narita Hospital.
Abstract:
A 63-year-old man with anemia was diagnosed as having cStage ⅣB gastric cancer with liver metastases. The patient was treated with SOX and nivolumab. After 3 courses of treatment, nivolumab administration was discontinued because of thyroiditis, and SOX was administered for 2 courses. Treatment resulted in RECIST: PR and surgery was planned. An indocyanine green(ICG)clearance test and 99mTc-GSA liver scintigraphy showed poor liver function, and liver biopsy revealed nivolumab-related hepatitis. After the recovery of liver function, the patient underwent total gastrectomy with splenectomy. However, he developed prolonged ascites postoperatively. Hepatitis/hepatotoxicity has been reported as an immune-related adverse event associated with nivolumab administration; however, its effect on surgery remains unknown.
