Related Experiment Video
Updated: Jul 27, 2026
A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies
Published on: July 28, 2020
Impact of fragmented care on retroperitoneal sarcomas
Denise L Wong1, Jordan Fredette2, Jill Hasler2
1Fox Chase Cancer Center Department of Surgical Oncology, 333 Cottman Avenue, Philadelphia, PA, 19111-2497, USA.
Background:
Fragmented care (FC) is associated with mixed outcomes. This analysis examines FC's impact on retroperitoneal sarcoma (RPS) treatment.
Methods:
The National Cancer Database was queried for adult patients with non-metastatic, surgically-resected RPS. FC was defined as diagnosis/treatment at >1 facility. Univariable and multivariable analyses examined factors associated with FC and its impact on overall survival.
Results:
4976 patients were included; 45.6 % experienced FC. Non-FC and FC cohorts were similar. Dedifferentiated liposarcoma were more common in FC cohort, as were poorly differentiated and undifferentiated tumors (p < 0.05). FC cohort had greater travel distance and time-to-treatment (both p < 0.001). Variables independently associated with FC included urban and rural setting and histology (poorly differentiated and undifferentiated) (all p < 0.05). After controlling for other variables, FC was not associated with survival.
Conclusion:
FC patients experienced longer distance travelled and time-to-treatment without survival impact. National emphasis must be placed on broadening access to equitable, high-quality sarcoma care.
