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Letter to the Editor: "Association between cardiovascular risk factors and dilated and hypertrophic cardiomyopathy:

Sari Luthfiyah1, Wannarat Lawang2, Fathimath Shifaza3

  • 1Department of Nursing, Poltekkes Kemenkes Surabaya, Surabaya, Indonesia.

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
|April 7, 2025
PubMed

Insights

Smoking and obesity causally increase the risk of dilated cardiomyopathy (DCM). This Mendelian randomization study highlights lifestyle factors crucial for preventing heart conditions like DCM.

Area of Science:

  • Cardiovascular epidemiology
  • Genetic epidemiology
  • Cardiology

Background:

  • Investigates causal links between lifestyle factors (smoking, alcohol, obesity) and cardiomyopathies (DCM, HCM).
  • Employs Mendelian randomization to infer causality, reducing observational bias.

Discussion:

  • Smoking and obesity show a significant causal association with increased risk of dilated cardiomyopathy (DCM).
  • Alcohol consumption and other factors examined did not demonstrate a significant causal link to DCM or HCM.
  • Highlights the utility of Mendelian randomization in understanding etiological pathways of cardiovascular diseases.

Key Insights:

  • Establishes a causal relationship between smoking, obesity, and dilated cardiomyopathy (DCM).
  • Provides evidence supporting smoking cessation and weight management as preventative strategies for DCM.

Outlook:

  • Future research should aim to increase genetic diversity in datasets for broader applicability.
  • Further investigation into the genetic determinants of cardiomyopathies is warranted.
  • Translating findings into public health interventions for cardiovascular disease prevention.

Keywords:
Cardiovascular risk factorsDilated cardiomyopathyHypertrophic cardiomyopathyMendelian randomizationSmoking and obesity

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