Effect of vitamin E on cholesterol plasma lipoprotein distribution and metabolism in rabbit

In the rabbit, after nine weeks on a basal synthetic diet supplemented with stripped corn oil and varying amount of vitamin E, plasma cholesterol level was depressed as the supplementation of vitamin E was increased. This hypocholesterolemic effect was accompanied by an increase in hepatic cholesterol-7 alpha-hydroxylase activity and cytochrome P-450 level and by a redistribution of plasma lipoprotein-cholesterol resulting in the elevation of high density to low density lipoprotein-cholesterol ratio.