Duodenal Amyloidosis Inducing Malabsorption in Hepatitis B-Related Liver Cirrhosis: A Rare Case Presentation

Chronic hepatitis B virus (HBV) infection is a major cause of liver cirrhosis worldwide. While hepatic complications are well-documented, extra-hepatic manifestations such as secondary amyloidosis are less common and can lead to diverse and complex clinical outcomes. Here, we present the case of a 60-year-old male with a history of chronic hepatitis B who progressed to liver cirrhosis and presented with chronic, unexplained, intractable diarrhea unresponsive to standard treatments. He also experienced significant unintentional weight loss and generalized weakness. Further investigations revealed amyloid deposition in the duodenum, confirming secondary amyloidosis affecting the gastrointestinal tract as the cause of malabsorption. Persistent diarrhea and malabsorption necessitated nutritional support and symptomatic management. This case highlights the rare association between chronic liver disease (CLD), secondary amyloidosis, and malabsorption syndrome, emphasizing the importance of clinical suspicion for timely diagnosis. Early recognition and prompt intervention are crucial to managing these complex cases, improving outcomes, and preventing further complications.