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Updated: May 15, 2025

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
Published on: July 16, 2017
Zepyros: a webserver to evaluate the shape complementarity of protein-protein interfaces
Mattia Miotto1, Lorenzo Di Rienzo1, Leonardo Bo'1
1Center for Life Nano & Neuroscience, Italian Institute of Technology, Rome 00161, Italy.
Motivation:
Shape complementarity of molecular surfaces at the interfaces is a well-known characteristic of protein-protein binding regions, and it is critical in influencing the stability of the complex. Measuring such complementarity is of great importance for a number of theoretical and practical implications; however, only a limited number of tools are currently available to efficiently and rapidly assess it.
Results:
Here, we introduce Zepyros (ZErnike Polynomials analYsis of pROtein Shapes), a webserver for fast measurement of the shape complementarity between two molecular interfaces of a given protein-protein complex using structural information. Zepyros is implemented as a publicly available tool with a user-friendly interface.
Availability And Implementation:
Our server can be found at the following link (all major browser supported): https://zepyros.bio-groups.com.
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