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Updated: May 15, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Hydrogen-Bond-Assisted Ru(III)-Catalyzed C-C Bond Activation in 1,3-Dicarbonyls: A Direct Route to Multi-Substituted
Santana Chakraborty1, Arijit Singha Mohapatra1, Nanda D Paul1
1Department of Chemistry, Indian Institute of Engineering Science and Technology, Shibpur, Botanic Garden, Howrah 711103, India.
Abstract:
Unprecedented CO-Cα bond cleavage of 1,3-dicarbonyls and enaminone, catalyzed by a well-defined Ru(III)-complex (1) featuring a redox-active triamine ligand (L) with a free -NH2 arm, opening a new route to accessing substituted pyrroles with broad substrate scope and functional group tolerance in good isolated yields via multicomponent coupling of 1,3-dicarbonyls, amines, and diol, is reported. The hydrogen bonding interaction offered by 1 facilitates the formation of critical reaction intermediates, favoring the formation of pyrroles.
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