Related Experiment Video

Updated: May 17, 2025

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
03:40

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

329

Managing Chronic Urticaria in Children: An Update

Luis Felipe Ensina1, Larissa Brandão2, Elena Netchiporouk3

  • 1Division of Allergy, Clinical Immunology and Rheumatology, Department of Pediatrics, Federal University of São Paulo, São Paulo, Brazil. 100alergia@gmail.com.

Current Allergy and Asthma Reports
|April 7, 2025
PubMed

Insights

Pediatric chronic urticaria is common and often resolves within two years. Effective treatments include H1-antihistamines, omalizumab, and potentially dupilumab, improving patient outcomes.

Area of Science:

  • Pediatric Dermatology
  • Allergy and Immunology
  • Clinical Therapeutics

Background:

  • Chronic urticaria (CU) in children presents unique diagnostic and therapeutic challenges.
  • Understanding pediatric CU prevalence and natural history is crucial for effective management.

Purpose of the Study:

  • To update current knowledge on pediatric chronic urticaria management.
  • To provide new insights into treatment strategies and patient outcomes.

Main Methods:

  • Review of recent literature on pediatric chronic urticaria.
  • Analysis of treatment efficacy, including antihistamines, omalizumab, and dupilumab.
  • Evaluation of patient-reported outcome measures (PROMs) in pediatric populations.

Main Results:

  • Pediatric CU may be more prevalent than previously recognized, with a high spontaneous resolution rate.
  • Patient-reported outcome measures (PROMs) are valuable for assessing disease severity and control.
  • Children with CU often show better response to H1-antihistamines than adults.
  • Omalizumab demonstrates excellent efficacy in antihistamine-refractory cases.
  • Dupilumab is an emerging treatment option for chronic spontaneous urticaria.

Conclusions:

  • Despite challenges, advancements in understanding disease mechanisms and novel therapies offer promise for pediatric CU.
  • Improved diagnostic tools and validated outcome measures enhance treatment effectiveness.
  • Personalized therapeutic approaches are key to optimizing outcomes for children with chronic urticaria.
Abstract

Keywords:
AngioedemaAntihistaminesAuto-immunityChildrenOmalizumabUrticaria

More Related Videos

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

38.7K
Basophil Activation Test for Allergy Diagnosis07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

7.9K

Related Concept Videos

Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
185
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
189
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
443
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.5K
Peptic Ulcer Disease IV: Management01:26

Peptic Ulcer Disease IV: Management

Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
55
Allergic Reactions02:06

Allergic Reactions

Overview
27.2K