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Managing Chronic Urticaria in Children: An Update
Luis Felipe Ensina1, Larissa Brandão2, Elena Netchiporouk3
1Division of Allergy, Clinical Immunology and Rheumatology, Department of Pediatrics, Federal University of São Paulo, São Paulo, Brazil. 100alergia@gmail.com.
Current Allergy and Asthma Reports
|April 7, 2025
Summary
Pediatric chronic urticaria is common and often resolves within two years. Effective treatments include H1-antihistamines, omalizumab, and potentially dupilumab, improving patient outcomes.
Area of Science:
- Pediatric Dermatology
- Allergy and Immunology
- Clinical Therapeutics
Background:
- Chronic urticaria (CU) in children presents unique diagnostic and therapeutic challenges.
- Understanding pediatric CU prevalence and natural history is crucial for effective management.
Purpose of the Study:
- To update current knowledge on pediatric chronic urticaria management.
- To provide new insights into treatment strategies and patient outcomes.
Main Methods:
- Review of recent literature on pediatric chronic urticaria.
- Analysis of treatment efficacy, including antihistamines, omalizumab, and dupilumab.
- Evaluation of patient-reported outcome measures (PROMs) in pediatric populations.
Main Results:
- Pediatric CU may be more prevalent than previously recognized, with a high spontaneous resolution rate.
- Patient-reported outcome measures (PROMs) are valuable for assessing disease severity and control.
- Children with CU often show better response to H1-antihistamines than adults.
- Omalizumab demonstrates excellent efficacy in antihistamine-refractory cases.
- Dupilumab is an emerging treatment option for chronic spontaneous urticaria.
Conclusions:
- Despite challenges, advancements in understanding disease mechanisms and novel therapies offer promise for pediatric CU.
- Improved diagnostic tools and validated outcome measures enhance treatment effectiveness.
- Personalized therapeutic approaches are key to optimizing outcomes for children with chronic urticaria.
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