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Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
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Post-vitrectomy endophthalmitis complicated with orbital cellulitis treated with hyperbaric oxygen therapy: A case
Yi-Ju Shen1, Li-Ching Liu1, I-Chia Liang1,2
1Department of Ophthalmology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, (R.O.C).
Medicine
|April 7, 2025
Summary
Hyperbaric oxygen therapy (HBOT) effectively treated severe infectious endophthalmitis in a silicone oil-filled eye. This approach, combined with antibiotics, shows promise for managing this rare but serious post-surgical complication.
Area of Science:
- Ophthalmology
- Hyperbaric Medicine
Background:
- Infectious endophthalmitis is a rare but severe complication following pars plana vitrectomy with silicone oil (SO) tamponade.
- Hyperbaric oxygen therapy (HBOT) has shown potential efficacy in treating infectious conditions like endophthalmitis and orbital cellulitis.
Purpose of the Study:
- To report a case of acute infectious endophthalmitis with orbital cellulitis and compartment syndrome in a postvitrectomy SO-filled eye.
- To evaluate the effectiveness of HBOT as an adjuvant treatment in such a complex case.
Main Methods:
- A 71-year-old female patient presented with eye swelling one week after pars plana vitrectomy and SO tamponade.
- Treatment involved intravitreal antibiotic injections and hyperbaric oxygen therapy (HBOT).
Main Results:
- The patient experienced acute infectious endophthalmitis complicated by orbital cellulitis and compartment syndrome.
- HBOT significantly ameliorated the severe soft tissue inflammation, compartment syndrome, and elevated intraocular pressure, which were refractory to other treatments.
Conclusions:
- HBOT demonstrated significant benefits in managing severe inflammation and compartment syndrome in this case.
- HBOT may serve as a valuable adjuvant therapy for endophthalmitis in SO-filled eyes, complementing antibiotics and surgical interventions.
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