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Updated: May 15, 2025

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
Visible-Light-Mediated Decarboxylative (Amino)Alkylation of Azomethine Imines
Seshadri Reddy Nasireddy1, Parashuram Sharma1, Kirti Khanna1
1Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, Uttar Pradesh 208016, India.
Abstract:
Herein, we report an efficient, organophotocatalyzed decarboxylative (amino)alkylation of azomethine imines using readily available carboxylic acids as alkylating agents. This transformation exhibits wide scope, and a variety of carboxylic acids, including glycine derivatives, were employed as radical precursors. The use of 4CzIPN as the photocatalyst allowed the application of nonbenzylic secondary and tertiary carboxylic acids also, overcoming previous limitations. The wide scope, applicability of nonprefunctionalized precursors, and mild conditions are the highlights of this method. The intermediacy of key radical intermediates was established by radical trapping experiments.
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